One of the main side effects of cannabis legalization will hopefully be a better public understanding of how cannabis works with the human body and how using cannabinoids for pain management could be an alternative to current solutions.
Cannabinoid use for pain relief is not a new concept, but in recent years we’ve seen an explosion in the development of new methods for using cannabinoids in ways to more effectively treat pain while limiting psychoactive effects on cognitive function. The general public has taken notice and the stigma associated with taking medical cannabis is rapidly dissipating as more people see cannabis as a desperately needed alternative to opioid medications.
Today, cannabinoid based medicine is being utilized by a wide range of people from pro athletes for injuries and soreness to the general public for any number of other painful conditions and ailments.
Cannabinoids and the endocannabinoid system
Put very simply, the endocannabinoid system manages a number of important functions for the human body including pain-sensation, memory, mood and much more. It’s also the system that allows cannabinoids to do their thing. It does this through a series of cannabinoid receptors found throughout the brain and nervous system known as CB1 and CB2 receptors. The body naturally produces chemical compounds known as endocannabinoids that react with these receptors to maintain homeostasis, a state of internal hormonal balance to counteract the fluctuating conditions of the external environment.
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The endocannabinoid system also receives external cannabinoids found in the cannabis plant, such as cannabidiol (CBD) and tetrahydrocannabinol (THC). This is what gives cannabinoids their therapeutic potential. Since the endocannabinoid system controls biological responses like pain, nausea, muscle relaxation/inflammation and more, external cannabinoids can be used to stimulate this system and treat imbalances.
Of the hundreds of cannabinoids that have been identified, the best known and understood are CBD and THC. These two cousins react with the endocannabinoid system in very different ways. The main functional difference between the two is that THC binds with both the CB1 and CB2 receptors while CBD does not bind with CB1 receptors. CB1 receptors are mostly found in the brain, which is why THC has that characteristic psychoactive effect that we associate with cannabis. CBD, on the other hand, interacts with receptors indirectly, affecting the way other compounds interact with the receptors and increasing the body’s production of naturally-produced endocannabinoids.
Nearly a century of prohibition has kept cannabinoids out of the hands of researchers and set back our understanding of the therapeutic potential of cannabinoids dramatically, but the growing body of evidence supports cannabinoids as a viable treatment for pain.
Using cannabinoids for pain management goes mainstream
With more jurisdictions legalizing and creating new legal cannabis markets, the global market for medical cannabis products is growing rapidly. According to a November 2018 report by Research and Markets the global medical cannabis market is projected to hit $37 billion in 2023, up from $11 billion in 2017. That’s a staggering 22 percent compound annual growth rate over seven years. Because the needs of medical users differ greatly from the preferences of recreational users major cannabis producers like Aurora Cannabis (TSX:ACB) and smaller players are investing millions into new and innovative medical products in order to meet the increasing demand from consumers seeking an alternative to opioid-based pain relief.
The world of professional sport has provided an arena for using cannabinoids for pain management and relief. So far these developments have focused mainly, but not exclusively, on CBD medicine, though athletes have been using THC for pain relief in unofficial capacities for some time. Studies and anecdotal evidence show the CBD’s anti-inflammatory properties could make it a useful tool for athletes looking for relief from soreness, muscle and joint damage or injuries that won’t affect physical or cognitive performance like many opioid medications or THC-rich cannabis.
UFC mixed martial artist Nick Diaz was famously seen vaping CBD oil during his post-match press conference after his 2016 loss to Conor McGregor. Diaz explained to the press that the oil was for post-fight muscle inflammation. The event caused controversy in the sport world at the time, but CBD was removed from the International Olympic Committee sanctioned anti-doping agency’s list of banned substances less than a year later. Other athletes including NFL linebacker Derrick Morgan and former tackle Eugene Monroe have also gone public with their use of CBD to treat sport-related ailments.
Cannabis pain relief players
The growth of the medical cannabis market has caused the emergence of a number of CBD players. NanoSphere Health Sciences (CSE:NSHS) is one such company. NanoSphere has been working on developing transdermal technology that improves the bioavailability of cannabinoids as they move through the bloodstream. The company’s Evolve Formulas Transdermal NanoSerum™ CBD utilizes a combination formula of synergistic cannabinoids, with each precision-metered dose containing 15mg of CBD and 1.5mg of THC. According to NanoSphere, this ‘nano-particle delivery’ technology will allow for more accurate dosing, making cannabis products more viable prescription options for health professionals.
Phivida Holdings (CSE:VIDA) is another medical cannabis company developing products for pain relief. In addition to other offerings, Phivida has developed a line of protein shakes aimed at the sports-oriented market and infused with a proprietary CBD blend designed specifically to aid muscle and joint repair and relieve post-workout pain and inflammation. Matica Enterprises (CSE:MMJ,FWB:39N,OTC Pink:MQPXF) is developing a topical time-release THC/CBD cream that medical cannabis patients that can be used to manage for pain management along with other ailments.
The pain relief pharmaceutical market is in desperate need of non-opioid based non-addictive pain relief options, and cannabis based medicine is poised to fill that void. As medical cannabis legalisation continues to spread across North America, Europe and beyond, the opportunities for companies developing these solutions continue to expand. Meanwhile growing understanding and acceptance of cannabinoid medicine spurred by high profile use in the professional sports industry and elsewhere will continue to open minds within these markets.
This article was written according to INN editorial standards to educate investors.
Ayurcann Holdings Corp. (CSE: AYUR) (the “Company” or “Ayurcann”) an integrated Canadian extraction company specializing in the processing of cannabis and hemp for the production of oils and various derivative products, announces the granting of stock options and restricted share units.
The Company has announced that it has granted incentive stock options to directors, officers, employees and consultants of the Company to purchase an aggregate of 1,000,100 common shares under the Company’s Stock Option Plan. Each option is exercisable at a price of $0.16 per common share, expires three years from the date of grant and vest six months from the date of the grant.
The Company has also granted restricted share unit grants, pursuant to the Company’s Restricted Share Unit plan, dated April 1, 2021, totaling 1,548,875 to certain eligible participants.
For further information, please contact:
Igal Sudman, Chairman, Chief Executive Officer and Corporate Secretary
Ayurcann Holdings Corp.
About Ayurcann Holdings Corp.:
Ayurcann is a leading post-harvest solution provider with a focus on providing and creating custom processes and pharma grade products for the adult use and medical cannabis industry in Canada. Ayurcann is focused on becoming the partner of choice for leading Canadian cannabis brands by providing best-in-class, proprietary services including ethanol extraction, formulation, product development and custom manufacturing.
Neither the Canadian Securities Exchange nor its Regulation Services Provider have reviewed or accept responsibility for the adequacy or accuracy of this release.
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A planned business merger between two leading cannabis producers hit a small delay this week as a critical vote got moved.
Keep reading to find out more cannabis highlights from the past five days.
Tilray delays critical shareholder meeting
On Thursday (April 15), Tilray (NASDAQ:TLRY) announced it will be postponing its shareholder vote on the fate of its merger with Aphria (NASDAQ:APHA,TSX:APHA). It will take place on April 30 instead of April 16.
Neither cannabis company offered an explanation for the change. Tilray has asked shareholders to participate in this vote regardless of how many shares they may hold. “Tilray stockholders who have not already voted, or wish to change their vote, are strongly encouraged to do so,” the company said.
This news came days after Aphria shareholders overwhelmingly voted in favor of the business transaction, with a total of 99.38 percent of shareholders voting for the deal to continue. Confirmation from Aphria Chairman and CEO Irwin Simon indicated the partnership was en route to being complete.
This past week Aphria also released financial results for the third quarter of its 2021 fiscal year, in which the firm highlights the overall direction of the company with the Tilray deal.
“We expect to have a tremendous runway for long-term sustainable growth as we build upon our existing foundation in Canada and internationally by increasing the scale of our global operations,” Simon said in a statement.
Cannabis retailer celebrates digital trend
Bidding for the piece, named “Non-Fungible Toke“ started at a price of C$4.20. The retailer plans to donate the proceeds to two charities, Second Harvest and Less.
The latter is designed to counter the carbon footprint of blockchain technology, a common criticism drawn against the rise of NFTs and other novel technologies.
As of 11:00 a.m. EST on Friday (April 16), the NFT bid was up to C$169.11.
Cannabis company news
- The Valens Company (TSX:VLNS,OTCQX:VLNCF) issued its financial report for the first quarter of its 2021 fiscal year. In its results, the company highlights a net revenue uptick of 24.7 percent from the previous quarter, resulting in C$20 million for the period.
- Trulieve Cannabis (CSE:TRUL,OTCQX:TCNNF) closed a public offering of 5 million subordinate voting shares at a price of C$50 each for total gross proceeds of C$287.5 million. The company celebrated its financial position after an offering in January, which will lead to the pursuit of merger and acquisition targets.
- Australis Capital (CSE:AUSA,OTCQB:AUSAF) appointed Jason Dyck as its new chief science officer and chairman of the firm’s scientific advisory board. Dyck previously served as an executive at Aurora Cannabis (NASDAQ:ACB,TSX:ACB), leading the scientific efforts for the cannabis producer. “I look forward to providing AUSA with advice and direction in its scientific efforts towards bringing innovations to market with immediate and significant commercial appeal,” Dyck said.
- Truss Beverage, a cannabis drinks venture co-owned by Molson Coors Beverage Company (NYSE:TAP,TSX:TPX) and HEXO (NYSE:HEXO,TSX:HEXO), released the details of its new lineup of infused beverages. Six new drinks will become available around the summer and are intended to pair with the season.
Don’t forget to follow us @INN_Cannabis for real-time updates!
Securities Disclosure: I, Bryan Mc Govern, hold no direct investment interest in any company mentioned in this article.
Partnerships with Minardi Law , Minorities for Medical Marijuana, CultivatED, and the Georgia Justice Project will include clinics and virtual events across Florida , Georgia , and Massachusetts
Trulieve Cannabis Corp. (CSE: TRUL) (OTCQX: TCNNF) (“Trulieve” or “the Company”), a leading and top-performing cannabis company based in the United States announced today a series of expungment clinics located throughout south and central Florida as well as virtual events in Georgia and Massachusetts . The clinics are part of the Company’s celebration of the 50 th anniversary of 420.
During the month of April, Minardi Law has hosted expungment clinics and will be hosting two more as follows:
- Releaf Patient Appreciation Day, April 17 th ( Valrico )
- First Annual 4/20 Event ( St. Petersburg Beach )
At these clinics, an attorney will be present to review records and see if someone is eligible for a sealing or expungment of their records. As part of the events, Trulieve will be helping cover the costs for finger prints, legal fees, and court costs.
Trulieve is working with Minorities for Medical Marijuana (“M4MM”) to host a 4/20 Expungement Clinic, part of M4MM’s Project Clean Slate. This event will take place on Saturday, April 24, 2021 , from 9:30am – 4:30pm at Riviera Beach City Hall. Anyone seeking to take place in this event is required to register in advance at http://trulieve.cc/expungementpreregistration .
In addition, Trulieve is sponsoring the First Friday Series , a weekly virtual event from the Georgia Justice Project to help Georgia citizens with record restrictions, and is also sponsoring the Fellowship Presentation and Expungement Clinic being offered through CultivateEd and GBLS on Friday, April 23 from 3:00pm – 4:00pm . You can register for the Massachusetts expungement clinic in advance here: HTTPS://BIT.LY/2Q655KK
“Our mission as a company has always been to improve people’s lives,” said Trulieve CEO Kim Rivers . “We’ve always been dedicated to improving the communities we call home. Partnering with Minardi Law , Minorities for Medical Marijuana, Georgia Justice Project and CultivatED on these clinics was a simple decision for us; we encourage anyone seeking help with the expungement process to attend one of these clinics in your own state to start the process.”
For more information about Trulieve and the April expungment clinics, please visit www.Trulieve.com .
Trulieve is primarily a vertically integrated “seed-to-sale” company in the U.S. and is the first and largest fully licensed medical cannabis company in the State of Florida . Trulieve cultivates and produces all of its products in-house and distributes those products to Trulieve-branded stores (dispensaries) throughout the State of Florida , as well as directly to patients via home delivery. Trulieve also has operations in California , Massachusetts , Connecticut and Pennsylvania. Trulieve is listed on the Canadian Securities Exchange under the symbol TRUL and trades on the OTCQX market under the symbol TCNNF.
To learn more about Trulieve, visit www.Trulieve.com .
SOURCE Trulieve Cannabis Corp.
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Seth Rogen’s New Cannabis Brand are Now Available at Apothecarium Dispensaries in San Francisco , Berkeley and Capitola
The Apothecarium is offering cannabis from Houseplant, the cannabis lifestyle brand founded by Seth Rogen and Evan Goldberg at its five California dispensaries. The Apothecarium has three San Francisco locations (Castro, SOMA and Marina ) and one each in Berkeley and Capitola (outside of Santa Cruz ).
“With the vast number of dispensaries in California , we put a lot of effort into identifying the right ones that align with Houseplant’s values,” said Seth Rogen , Co-Founder of Houseplant. “The Apothecarium shares the same commitment to creating a strong consumer experience that we pride ourselves on and we are thrilled to bring our three initial strains to their stores in the Bay Area.”
Houseplant is launching with three flower strains, all of which will be available at The Apothecarium, including: Diablo Wind (sativa), Pancake Ice (sativa) and Pink Moon (indica). Like their founder’s groundbreaking film “Pineapple Express”, Houseplant strains are named after weather phenomena. Each strain will be sold in a custom tin.
“We are so proud to be one of the very first dispensaries in California to offer Houseplant to our customers,” said Ryan Hudson , CEO and co-founder of The Apothecarium. “Seth, Evan and everyone at Houseplant love and respect cannabis as much as we do. We simply cannot wait to share their beautiful and delicious flowers with our guests.”
“We’ve been working with the Houseplant team for more than a year and are grateful to have a partner that shares so many of our values, including an emphasis on cannabis education, quality, reform of cannabis laws and beautifully designed, recyclable packaging.”
“Seth has been hands-on during the process, spending time with our store managers to make sure they know the products and how much care has gone into vetting and selecting the best strains. We think our guests are going to love Houseplant.”
About The Apothecarium
The Apothecarium is recognized as one of the nation’s premier cannabis dispensaries, with an emphasis on education via in-depth one-on-one consultations from highly trained cannabis consultants. The company was founded by three first cousins and two family friends in 2011. Our dispensaries are known for providing educational events that are open to the public at no cost — and for welcoming seniors, first-time dispensary visitors, and people with serious medical conditions. The Apothecarium’s flagship San Francisco dispensary was named the best-designed dispensary in the country by Architectural Digest . Patients and customers may order at our dispensaries or online for pickup or delivery at apothecarium.com [apothecarium.com] .
The Apothecarium is committed to giving back to the communities we serve. We have donated more than $400,000 in cash to community groups and nonprofits — plus more than $300,000 worth of in-kind donations.
All Apothecarium dispensaries continue to implement safety measures to protect guests and team members. Protocols include strict social distancing inside and outside the dispensaries, a mask requirement for everyone inside the dispensaries, no contact check-in procedures and ongoing sanitizing throughout the day.
CA Licenses: C10-0000523-LIC; C10-0000522-LIC; C10-0000515-LIC, C10-0000738-LIC, C10-0000706-LIC
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MISSISSAUGA, Ontario TheNewswire – April 16, 2021 Sire Bioscience Inc. (CSE:SIRE) (OTC:BLLXF) (FSE:BR1B) (CNSX:SIRE.CN) (“SIRE” or the “Company”) announces that Brian Nugent has resigned as a member of the Company’s board of directors (the “ Board ”). It has been a pleasure and a blessing to have worked with Brian Nugent over the past few years, his business acumen and tremendous experience will certainly be missed, SIRE wishes him nothing but the best in all his future endeavors.
About Sire Bioscience
SIRE is headquartered in Mississauga, Ontario with its wholly owned subsidiary PLANTFUEL® based in Denver, Colorado. SIRE is managed by a group of successful entrepreneurs who have extensive experience in the areas of consumer-packaged goods, manufacturing, logistics, and distribution. SIRE is a CPG life science company focused on the plant-based foods and supplements industry.
For additional information contact:
Sire Bioscience Inc.
Copyright (c) 2021 TheNewswire – All rights reserved.
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