As legal cannabis products find their place in the North American markets, it’s the other cannabinoid that’s getting a lot of the buzz, as well as spurring on innovation in the cannabis space.

Cannabidiol (CBD) doesn’t get the user high, but it does reduce chronic pain and inflammation and a growing body of research suggests it could be useful for treating epilepsy, anxiety, post-traumatic stress disorder and more.


Despite shifting and uncertain regulatory landscapes, cannabis and hemp companies in Canada and the United States are betting big on CBD, investing in new and innovative formulas, formats, and precision dosing methods.

A brief explanation and history of CBD

CBD reacts differently with the endocannabinoid system—the system in the brain and nervous system that manages pain-sensation, memory, mood and more—than it’s cousin THC. Whereas THC binds directly to the system’s cannabinoid receptors to stimulate things like dopamine production, CBD reacts indirectly with the receptors and increases the body’s production of naturally-produced endocannabinoids.

With the sudden rush of attention around CBD in recent years, one could be forgiven for thinking that it’s a new discovery. In reality, CBD was first isolated from the cannabis plant all the way back in 1940. However, it would be a long time before we came to understand its potential. As with any medicinal drug, and particularly with one associated with cannabis, the road to understanding and legitimacy has been long and slow for CBD.

Dr. Roger Adams and a team of chemists at the university of Illinois were the first to discover the compound, though based on the paper that the team published in 1940, it’s clear that Adams and his team had no idea what they had discovered. The paper described CBD as “very toxic,” something we now know to be far from the truth.

It would take until 1963 for researchers to take another serious look at CBD when Dr. Raphael Mechoulam of the Hebrew University of Jerusalem determined the compound’s exact structure, opening CBD up for research as a pharmacological substance. In 1973, the first suggestions of CBD’s therapeutic potential were made when Brazilian researchers found reductions of the symptoms of epilepsy in animals. Further studies over the following two decades yielded promising results, showing a diminishment of convulsions in epilepsy patients, and promise for treating psychosis and anxiety. The discovery of the endocannabinoid system in 1988 shed light on how cannabinoids naturally work with the human body and further increased interest in cannabinoids as therapeutic medicine.

This research continued into the 21st century but it would be the plight of a little girl in Colorado that would bring the compound to mainstream attention. The high CBD/low THC cannabis strain Charlotte’s Web was developed in 2011 and named for Charlotte Figi, a then five-year-old girl with Dravet Syndrome, who was suffering from up to 300 grand mal seizures each week. As numerous other medications and therapies failed to help and Charlotte’s quality of life rapidly declined, her parents turned to CBD, a treatment that was unheard of for children at the time and extremely controversial. To the astonishment of Charlotte’s parents and physicians, the hail mary treatment did in fact reduce her seizures, completely.

Charlotte’s story attracted serious media attention from outlets all over the world, bringing attention and education on medicinal CBD to the public. Since then, the market for CBD products has exploded. CBD is now commonly used for serious disorders like Charlotte’s, for chronic pain and ailments, and as a general health and wellness product.

Today’s CBD market driving innovation in the cannabis space

The CBD market has evolved significantly from its days as a last resort treatment for people like Charlotte. As CBD’s benefits become increasingly and widely understood, and as innovation has opened new segments, the market is expected to have a compound annual growth rate of  39.19 percent up to 2021.

Today, with CBD products increasingly available throughout Canada and the United

States, innovation is the name of the game for CBD players looking to set themselves apart from the competition. To that end, CBD products can now be found in a huge range of forms. These include the standard tinctures of oil, edible products like candies, sport drinks and protein shakes formulated specifically to aid with post-workout aches and pains. Skin care product manufacturers have also taken notice of CBD’s utility for improving the look and feel of skin when used topically and have partnered with licenced producers to integrate CBD into their products.

Another big area of innovation in the CBD space is in precision dosing technology. Since cannabis and CBD products first began gaining steam as medicinal and wellness products, the question has been how best to ensure consumers are getting consistent and exact dosages for their specific needs. A number of companies in the space have worked out solutions. Canadian licensed producer Emblem Corp (TSXV:EMC,OTCQX:EMMBF) has partnered with Canntab Therapeutics (CSE:PILL) for the exclusive right to utilize Canntab’s Extended Release (XR) cannabis tablets in Canada. These proprietary time-released tablets are designed to release a predetermined and consistent portion of cannabinoids over an extended period of time, giving the consumer a longer lasting period of effect with reduced worry of side effects.

NanoSphere Health Sciences (CSE:NSHS) is another company focused on precision dosing technology. Nanosphere’s proprietary ‘nano-particle delivery’ system uses nanotechnology to encase cannabinoids in a phospholipid membrane similar to the membranes that protect cells in the body. This method ensures that a greater percentage of cannabinoids make it into the bloodstream, allowing for a more predictable dosage.

Regulatory status in Canada and the United States

In both Canada and the United States, the market is shifting in ways that create new opportunity for CBD products. Cannabis products, including CBD, remain illegal at the federal level in the US, but CBD is increasingly being allowed even in states that maintain tight prohibitions on THC cannabis. Currently, all but three US states have made exceptions to their anti-cannabis laws to allow for the sale of CBD. Federally, upcoming potential changes to the Farm Act could end the country’s prohibition on THC-free hemp, from which CBD can be extracted. The United States opening doors for CBD is one of the driving factors that could cause the American CBD market to grow faster than the legal THC cannabis market.

In Canada, the cannabis act will allow for the sale of recreational cannabis to adults, with tight restriction. Some licensed producers are hopeful that this massive regulatory shift will open the door for parliament to remove hemp-derived CBD from the controlled substances list entirely. This move would allow CBD products to move out of the dispensary and into broader market places like grocery stores and mainstream drugstores, allowing for a wider market reach for CBD.

This article was written by INN according to INN editorial standards to educate investors.

Trulieve to donate $20,000 in scholarship funding and $15,000 to support leadership development

Trulieve Cannabis Corp . (CSE: TRUL) (OTC: TCNNF), a leading and top-performing cannabis company in the United States today announced a new partnership with the Thurgood Marshall College Fund (TMCF), the nation’s largest organization exclusively representing the Black College Community. Trulieve will donate $20,000 to help fund several college scholarships awarded to students who are attending one of the organization’s member-schools as part of Trulieve’s diversity, equity, and inclusion initiatives. The $15,000 in talent funding is earmarked to support TMCF’s internship program, reaching a diverse talent pool of students and alumni from their 47 member-schools to provide immersive experiences at Trulieve.

Keep reading... Show less

The new dispensary expands patient access to Florida’s largest inventory of medical cannabis products

Trulieve Cannabis Corp. (CSE: TRUL) (OTCQX: TCNNF) (“Trulieve” or “the Company”), a leading and top-performing cannabis company based in the United States announced today the opening of a brand-new Florida dispensary, the Company’s 80th nationwide. The new location marks the Company’s first in Tamarac and third in Broward County expanding patient access to Florida’s largest and broadest assortment of high-quality medical cannabis products.

Keep reading... Show less

Revive Therapeutics Ltd. (“Revive” or the “Company”) (CSE: RVV, USA: RVVTF), a specialty life sciences company focused on the research and development of therapeutics for medical needs and rare disorders, is pleased to announce an update on the Company’s U.S. Food & Drug Administration (“FDA”) Phase 3 clinical trial (the “Study”) to evaluate the safety and efficacy of Bucillamine in patients with mild to moderate COVID-19.

With its recent $23 million dollar financing, the Company plans to aggressively expand from 14 clinical sites to up to 50 clinical sites to meet the next enrollment goals for the Study in Q2-2020. The Study is a randomized, double-blinded, placebo-controlled trial and the safety and efficacy data analyzed at each interim analysis timepoint of 210, 400, 600 and 800 completed patients are only made available to the Independent Data and Safety Monitoring Board (“DSMB”) for review and recommendations on continuation, stopping or changes to the conduct of the Study. In the event of any serious safety concerns, the DSMB would be notified to determine any risks and provide its recommendations. To date, in this initial 210 interim point there have been no serious safety concerns that required the DSMB to be notified.

Keep reading... Show less

HempFusion Wellness Inc. (TSX:CBD.U) (OTCQX:CBDHF) (FWB:8OO) (“HempFusion” or the “Company”), a leading health and wellness CBD company utilizing the power of whole-food hemp nutrition, is pleased to announce that its common shares have been approved for DTC full-service eligibility in the United States by the Depository Trust Company (“DTC”) and can now be both traded and serviced through DTC’s electronic book-entry system.

DTC is a subsidiary of the Depository Trust & Clearing Corp. (“DTCC”) that provides clearing and settlement services for the financial markets and settles the majority of securities transactions in the United States. This electronic method of clearing securities speeds up the receipt of stock and cash and thus accelerates the settlement process for investors and brokers, enabling the stock to be traded over a much wider selection of brokerage firms.

Keep reading... Show less

CFN Enterprises Inc. (OTCQB: CNFN) (CFN Media) partners with FMW Media Works LLC to produce a regular series on the global cannabis markets to air on major financial news networks across the US. Initial segment features leading cannabis analyst and US Multi-State Operator (MSO)

CFN Enterprises Inc. (OTCQB: CNFN), owner and operator of CFN Media, the leading media network dedicated to the global legal cannabis, CBD and psychedelics industries, today announced that its inaugural news segment on the cannabis markets, “Cannabis Market Outlook for 2021,” will air on Bloomberg, Newsmax and Fox Business.

Keep reading... Show less